google-api-ruby-client/generated/google/apis/genomics_v1/service.rb

# Copyright 2015 Google Inc.
#
# Licensed under the Apache License, Version 2.0 (the "License");
# you may not use this file except in compliance with the License.
# You may obtain a copy of the License at
#
#      http://www.apache.org/licenses/LICENSE-2.0
#
# Unless required by applicable law or agreed to in writing, software
# distributed under the License is distributed on an "AS IS" BASIS,
# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
# See the License for the specific language governing permissions and
# limitations under the License.

require 'google/apis/core/base_service'
require 'google/apis/core/json_representation'
require 'google/apis/core/hashable'
require 'google/apis/errors'

module Google
  module Apis
    module GenomicsV1
      # Genomics API
      #
      # Upload, process, query, and search Genomics data in the cloud.
      #
      # @example
      #    require 'google/apis/genomics_v1'
      #
      #    Genomics = Google::Apis::GenomicsV1 # Alias the module
      #    service = Genomics::GenomicsService.new
      #
      # @see https://cloud.google.com/genomics
      class GenomicsService < Google::Apis::Core::BaseService
        # @return [String]
        #  API key. Your API key identifies your project and provides you with API access,
        #  quota, and reports. Required unless you provide an OAuth 2.0 token.
        attr_accessor :key

        # @return [String]
        #  Available to use for quota purposes for server-side applications. Can be any
        #  arbitrary string assigned to a user, but should not exceed 40 characters.
        attr_accessor :quota_user

        def initialize
          super('https://genomics.googleapis.com/', '')
        end
        
        # Deletes a read group set.
        # For the definitions of read group sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] read_group_set_id
        #   The ID of the read group set to be deleted. The caller must have WRITE
        #   permissions to the dataset associated with this read group set.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Empty] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Empty]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def delete_read_group_set(read_group_set_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:delete, 'v1/readgroupsets/{readGroupSetId}', options)
          command.response_representation = Google::Apis::GenomicsV1::Empty::Representation
          command.response_class = Google::Apis::GenomicsV1::Empty
          command.params['readGroupSetId'] = read_group_set_id unless read_group_set_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Creates read group sets by asynchronously importing the provided
        # information.
        # For the definitions of read group sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # The caller must have WRITE permissions to the dataset.
        # ## Notes on [BAM](https://samtools.github.io/hts-specs/SAMv1.pdf) import
        # - Tags will be converted to strings - tag types are not preserved
        # - Comments (`@CO`) in the input file header will not be preserved
        # - Original header order of references (`@SQ`) will not be preserved
        # - Any reverse stranded unmapped reads will be reverse complemented, and
        # their qualities (also the "BQ" and "OQ" tags, if any) will be reversed
        # - Unmapped reads will be stripped of positional information (reference name
        # and position)
        # @param [Google::Apis::GenomicsV1::ImportReadGroupSetsRequest] import_read_group_sets_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Operation] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Operation]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def import_read_group_sets(import_read_group_sets_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/readgroupsets:import', options)
          command.request_representation = Google::Apis::GenomicsV1::ImportReadGroupSetsRequest::Representation
          command.request_object = import_read_group_sets_request_object
          command.response_representation = Google::Apis::GenomicsV1::Operation::Representation
          command.response_class = Google::Apis::GenomicsV1::Operation
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Exports a read group set to a BAM file in Google Cloud Storage.
        # For the definitions of read group sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Note that currently there may be some differences between exported BAM
        # files and the original BAM file at the time of import. See
        # ImportReadGroupSets
        # for caveats.
        # @param [String] read_group_set_id
        #   Required. The ID of the read group set to export. The caller must have
        #   READ access to this read group set.
        # @param [Google::Apis::GenomicsV1::ExportReadGroupSetRequest] export_read_group_set_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Operation] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Operation]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def export_read_group_sets(read_group_set_id, export_read_group_set_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/readgroupsets/{readGroupSetId}:export', options)
          command.request_representation = Google::Apis::GenomicsV1::ExportReadGroupSetRequest::Representation
          command.request_object = export_read_group_set_request_object
          command.response_representation = Google::Apis::GenomicsV1::Operation::Representation
          command.response_class = Google::Apis::GenomicsV1::Operation
          command.params['readGroupSetId'] = read_group_set_id unless read_group_set_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Searches for read group sets matching the criteria.
        # For the definitions of read group sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Implements
        # [GlobalAllianceApi.searchReadGroupSets](https://github.com/ga4gh/schemas/blob/
        # v0.5.1/src/main/resources/avro/readmethods.avdl#L135).
        # @param [Google::Apis::GenomicsV1::SearchReadGroupSetsRequest] search_read_group_sets_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::SearchReadGroupSetsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::SearchReadGroupSetsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def search_read_group_sets(search_read_group_sets_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/readgroupsets/search', options)
          command.request_representation = Google::Apis::GenomicsV1::SearchReadGroupSetsRequest::Representation
          command.request_object = search_read_group_sets_request_object
          command.response_representation = Google::Apis::GenomicsV1::SearchReadGroupSetsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::SearchReadGroupSetsResponse
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Updates a read group set.
        # For the definitions of read group sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # This method supports patch semantics.
        # @param [String] read_group_set_id
        #   The ID of the read group set to be updated. The caller must have WRITE
        #   permissions to the dataset associated with this read group set.
        # @param [Google::Apis::GenomicsV1::ReadGroupSet] read_group_set_object
        # @param [String] update_mask
        #   An optional mask specifying which fields to update. Supported fields:
        #   * name.
        #   * referenceSetId.
        #   Leaving `updateMask` unset is equivalent to specifying all mutable
        #   fields.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::ReadGroupSet] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::ReadGroupSet]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def patch_read_group_set(read_group_set_id, read_group_set_object = nil, update_mask: nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:patch, 'v1/readgroupsets/{readGroupSetId}', options)
          command.request_representation = Google::Apis::GenomicsV1::ReadGroupSet::Representation
          command.request_object = read_group_set_object
          command.response_representation = Google::Apis::GenomicsV1::ReadGroupSet::Representation
          command.response_class = Google::Apis::GenomicsV1::ReadGroupSet
          command.params['readGroupSetId'] = read_group_set_id unless read_group_set_id.nil?
          command.query['updateMask'] = update_mask unless update_mask.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets a read group set by ID.
        # For the definitions of read group sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] read_group_set_id
        #   The ID of the read group set.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::ReadGroupSet] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::ReadGroupSet]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def get_read_group_set(read_group_set_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/readgroupsets/{readGroupSetId}', options)
          command.response_representation = Google::Apis::GenomicsV1::ReadGroupSet::Representation
          command.response_class = Google::Apis::GenomicsV1::ReadGroupSet
          command.params['readGroupSetId'] = read_group_set_id unless read_group_set_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Lists fixed width coverage buckets for a read group set, each of which
        # correspond to a range of a reference sequence. Each bucket summarizes
        # coverage information across its corresponding genomic range.
        # For the definitions of read group sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Coverage is defined as the number of reads which are aligned to a given
        # base in the reference sequence. Coverage buckets are available at several
        # precomputed bucket widths, enabling retrieval of various coverage 'zoom
        # levels'. The caller must have READ permissions for the target read group
        # set.
        # @param [String] read_group_set_id
        #   Required. The ID of the read group set over which coverage is requested.
        # @param [String] reference_name
        #   The name of the reference to query, within the reference set associated
        #   with this query. Optional.
        # @param [String] end_
        #   The end position of the range on the reference, 0-based exclusive. If
        #   specified, `referenceName` must also be specified. If unset or 0, defaults
        #   to the length of the reference.
        # @param [String] page_token
        #   The continuation token, which is used to page through large result sets.
        #   To get the next page of results, set this parameter to the value of
        #   `nextPageToken` from the previous response.
        # @param [Fixnum] page_size
        #   The maximum number of results to return in a single page. If unspecified,
        #   defaults to 1024. The maximum value is 2048.
        # @param [String] start
        #   The start position of the range on the reference, 0-based inclusive. If
        #   specified, `referenceName` must also be specified. Defaults to 0.
        # @param [String] target_bucket_width
        #   The desired width of each reported coverage bucket in base pairs. This
        #   will be rounded down to the nearest precomputed bucket width; the value
        #   of which is returned as `bucketWidth` in the response. Defaults
        #   to infinity (each bucket spans an entire reference sequence) or the length
        #   of the target range, if specified. The smallest precomputed
        #   `bucketWidth` is currently 2048 base pairs; this is subject to
        #   change.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::ListCoverageBucketsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::ListCoverageBucketsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def list_coverage_buckets(read_group_set_id, reference_name: nil, end_: nil, page_token: nil, page_size: nil, start: nil, target_bucket_width: nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/readgroupsets/{readGroupSetId}/coveragebuckets', options)
          command.response_representation = Google::Apis::GenomicsV1::ListCoverageBucketsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::ListCoverageBucketsResponse
          command.params['readGroupSetId'] = read_group_set_id unless read_group_set_id.nil?
          command.query['referenceName'] = reference_name unless reference_name.nil?
          command.query['end'] = end_ unless end_.nil?
          command.query['pageToken'] = page_token unless page_token.nil?
          command.query['pageSize'] = page_size unless page_size.nil?
          command.query['start'] = start unless start.nil?
          command.query['targetBucketWidth'] = target_bucket_width unless target_bucket_width.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets a list of reads for one or more read group sets.
        # For the definitions of read group sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Reads search operates over a genomic coordinate space of reference sequence
        # & position defined over the reference sequences to which the requested
        # read group sets are aligned.
        # If a target positional range is specified, search returns all reads whose
        # alignment to the reference genome overlap the range. A query which
        # specifies only read group set IDs yields all reads in those read group
        # sets, including unmapped reads.
        # All reads returned (including reads on subsequent pages) are ordered by
        # genomic coordinate (by reference sequence, then position). Reads with
        # equivalent genomic coordinates are returned in an unspecified order. This
        # order is consistent, such that two queries for the same content (regardless
        # of page size) yield reads in the same order across their respective streams
        # of paginated responses.
        # Implements
        # [GlobalAllianceApi.searchReads](https://github.com/ga4gh/schemas/blob/v0.5.1/
        # src/main/resources/avro/readmethods.avdl#L85).
        # @param [Google::Apis::GenomicsV1::SearchReadsRequest] search_reads_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::SearchReadsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::SearchReadsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def search_reads(search_reads_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/reads/search', options)
          command.request_representation = Google::Apis::GenomicsV1::SearchReadsRequest::Representation
          command.request_object = search_reads_request_object
          command.response_representation = Google::Apis::GenomicsV1::SearchReadsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::SearchReadsResponse
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Deletes a call set.
        # For the definitions of call sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] call_set_id
        #   The ID of the call set to be deleted.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Empty] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Empty]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def delete_call_set(call_set_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:delete, 'v1/callsets/{callSetId}', options)
          command.response_representation = Google::Apis::GenomicsV1::Empty::Representation
          command.response_class = Google::Apis::GenomicsV1::Empty
          command.params['callSetId'] = call_set_id unless call_set_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets a list of call sets matching the criteria.
        # For the definitions of call sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Implements
        # [GlobalAllianceApi.searchCallSets](https://github.com/ga4gh/schemas/blob/v0.5.
        # 1/src/main/resources/avro/variantmethods.avdl#L178).
        # @param [Google::Apis::GenomicsV1::SearchCallSetsRequest] search_call_sets_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::SearchCallSetsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::SearchCallSetsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def search_call_sets(search_call_sets_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/callsets/search', options)
          command.request_representation = Google::Apis::GenomicsV1::SearchCallSetsRequest::Representation
          command.request_object = search_call_sets_request_object
          command.response_representation = Google::Apis::GenomicsV1::SearchCallSetsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::SearchCallSetsResponse
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Updates a call set.
        # For the definitions of call sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # This method supports patch semantics.
        # @param [String] call_set_id
        #   The ID of the call set to be updated.
        # @param [Google::Apis::GenomicsV1::CallSet] call_set_object
        # @param [String] update_mask
        #   An optional mask specifying which fields to update. At this time, the only
        #   mutable field is name. The only
        #   acceptable value is "name". If unspecified, all mutable fields will be
        #   updated.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::CallSet] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::CallSet]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def patch_call_set(call_set_id, call_set_object = nil, update_mask: nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:patch, 'v1/callsets/{callSetId}', options)
          command.request_representation = Google::Apis::GenomicsV1::CallSet::Representation
          command.request_object = call_set_object
          command.response_representation = Google::Apis::GenomicsV1::CallSet::Representation
          command.response_class = Google::Apis::GenomicsV1::CallSet
          command.params['callSetId'] = call_set_id unless call_set_id.nil?
          command.query['updateMask'] = update_mask unless update_mask.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets a call set by ID.
        # For the definitions of call sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] call_set_id
        #   The ID of the call set.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::CallSet] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::CallSet]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def get_call_set(call_set_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/callsets/{callSetId}', options)
          command.response_representation = Google::Apis::GenomicsV1::CallSet::Representation
          command.response_class = Google::Apis::GenomicsV1::CallSet
          command.params['callSetId'] = call_set_id unless call_set_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Creates a new call set.
        # For the definitions of call sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [Google::Apis::GenomicsV1::CallSet] call_set_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::CallSet] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::CallSet]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def create_call_set(call_set_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/callsets', options)
          command.request_representation = Google::Apis::GenomicsV1::CallSet::Representation
          command.request_object = call_set_object
          command.response_representation = Google::Apis::GenomicsV1::CallSet::Representation
          command.response_class = Google::Apis::GenomicsV1::CallSet
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Creates a new annotation set. Caller must have WRITE permission for the
        # associated dataset.
        # The following fields are required:
        # * datasetId
        # * referenceSetId
        # All other fields may be optionally specified, unless documented as being
        # server-generated (for example, the `id` field).
        # @param [Google::Apis::GenomicsV1::AnnotationSet] annotation_set_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::AnnotationSet] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::AnnotationSet]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def create_annotation_set(annotation_set_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/annotationsets', options)
          command.request_representation = Google::Apis::GenomicsV1::AnnotationSet::Representation
          command.request_object = annotation_set_object
          command.response_representation = Google::Apis::GenomicsV1::AnnotationSet::Representation
          command.response_class = Google::Apis::GenomicsV1::AnnotationSet
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Deletes an annotation set. Caller must have WRITE permission
        # for the associated annotation set.
        # @param [String] annotation_set_id
        #   The ID of the annotation set to be deleted.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Empty] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Empty]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def delete_annotationset(annotation_set_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:delete, 'v1/annotationsets/{annotationSetId}', options)
          command.response_representation = Google::Apis::GenomicsV1::Empty::Representation
          command.response_class = Google::Apis::GenomicsV1::Empty
          command.params['annotationSetId'] = annotation_set_id unless annotation_set_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Searches for annotation sets that match the given criteria. Annotation sets
        # are returned in an unspecified order. This order is consistent, such that
        # two queries for the same content (regardless of page size) yield annotation
        # sets in the same order across their respective streams of paginated
        # responses. Caller must have READ permission for the queried datasets.
        # @param [Google::Apis::GenomicsV1::SearchAnnotationSetsRequest] search_annotation_sets_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::SearchAnnotationSetsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::SearchAnnotationSetsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def search_annotationset_annotation_sets(search_annotation_sets_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/annotationsets/search', options)
          command.request_representation = Google::Apis::GenomicsV1::SearchAnnotationSetsRequest::Representation
          command.request_object = search_annotation_sets_request_object
          command.response_representation = Google::Apis::GenomicsV1::SearchAnnotationSetsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::SearchAnnotationSetsResponse
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets an annotation set. Caller must have READ permission for
        # the associated dataset.
        # @param [String] annotation_set_id
        #   The ID of the annotation set to be retrieved.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::AnnotationSet] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::AnnotationSet]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def get_annotation_set(annotation_set_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/annotationsets/{annotationSetId}', options)
          command.response_representation = Google::Apis::GenomicsV1::AnnotationSet::Representation
          command.response_class = Google::Apis::GenomicsV1::AnnotationSet
          command.params['annotationSetId'] = annotation_set_id unless annotation_set_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Updates an annotation set. The update must respect all mutability
        # restrictions and other invariants described on the annotation set resource.
        # Caller must have WRITE permission for the associated dataset.
        # @param [String] annotation_set_id
        #   The ID of the annotation set to be updated.
        # @param [Google::Apis::GenomicsV1::AnnotationSet] annotation_set_object
        # @param [String] update_mask
        #   An optional mask specifying which fields to update. Mutable fields are
        #   name,
        #   source_uri, and
        #   info. If unspecified, all
        #   mutable fields will be updated.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::AnnotationSet] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::AnnotationSet]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def update_annotationset(annotation_set_id, annotation_set_object = nil, update_mask: nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:put, 'v1/annotationsets/{annotationSetId}', options)
          command.request_representation = Google::Apis::GenomicsV1::AnnotationSet::Representation
          command.request_object = annotation_set_object
          command.response_representation = Google::Apis::GenomicsV1::AnnotationSet::Representation
          command.response_class = Google::Apis::GenomicsV1::AnnotationSet
          command.params['annotationSetId'] = annotation_set_id unless annotation_set_id.nil?
          command.query['updateMask'] = update_mask unless update_mask.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Deletes a variant.
        # For the definitions of variants and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] variant_id
        #   The ID of the variant to be deleted.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Empty] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Empty]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def delete_variant(variant_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:delete, 'v1/variants/{variantId}', options)
          command.response_representation = Google::Apis::GenomicsV1::Empty::Representation
          command.response_class = Google::Apis::GenomicsV1::Empty
          command.params['variantId'] = variant_id unless variant_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Creates variant data by asynchronously importing the provided information.
        # For the definitions of variant sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # The variants for import will be merged with any existing variant that
        # matches its reference sequence, start, end, reference bases, and
        # alternative bases. If no such variant exists, a new one will be created.
        # When variants are merged, the call information from the new variant
        # is added to the existing variant, and Variant info fields are merged
        # as specified in
        # infoMergeConfig.
        # As a special case, for single-sample VCF files, QUAL and FILTER fields will
        # be moved to the call level; these are sometimes interpreted in a
        # call-specific context.
        # Imported VCF headers are appended to the metadata already in a variant set.
        # @param [Google::Apis::GenomicsV1::ImportVariantsRequest] import_variants_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Operation] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Operation]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def import_variants(import_variants_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/variants:import', options)
          command.request_representation = Google::Apis::GenomicsV1::ImportVariantsRequest::Representation
          command.request_object = import_variants_request_object
          command.response_representation = Google::Apis::GenomicsV1::Operation::Representation
          command.response_class = Google::Apis::GenomicsV1::Operation
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Merges the given variants with existing variants.
        # For the definitions of variants and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Each variant will be
        # merged with an existing variant that matches its reference sequence,
        # start, end, reference bases, and alternative bases. If no such variant
        # exists, a new one will be created.
        # When variants are merged, the call information from the new variant
        # is added to the existing variant. Variant info fields are merged as
        # specified in the
        # infoMergeConfig
        # field of the MergeVariantsRequest.
        # Please exercise caution when using this method!  It is easy to introduce
        # mistakes in existing variants and difficult to back out of them.  For
        # example,
        # suppose you were trying to merge a new variant with an existing one and
        # both
        # variants contain calls that belong to callsets with the same callset ID.
        # // Existing variant - irrelevant fields trimmed for clarity
        # `
        # "variantSetId": "10473108253681171589",
        # "referenceName": "1",
        # "start": "10582",
        # "referenceBases": "G",
        # "alternateBases": [
        # "A"
        # ],
        # "calls": [
        # `
        # "callSetId": "10473108253681171589-0",
        # "callSetName": "CALLSET0",
        # "genotype": [
        # 0,
        # 1
        # ],
        # `
        # ]
        # `
        # // New variant with conflicting call information
        # `
        # "variantSetId": "10473108253681171589",
        # "referenceName": "1",
        # "start": "10582",
        # "referenceBases": "G",
        # "alternateBases": [
        # "A"
        # ],
        # "calls": [
        # `
        # "callSetId": "10473108253681171589-0",
        # "callSetName": "CALLSET0",
        # "genotype": [
        # 1,
        # 1
        # ],
        # `
        # ]
        # `
        # The resulting merged variant would overwrite the existing calls with those
        # from the new variant:
        # `
        # "variantSetId": "10473108253681171589",
        # "referenceName": "1",
        # "start": "10582",
        # "referenceBases": "G",
        # "alternateBases": [
        # "A"
        # ],
        # "calls": [
        # `
        # "callSetId": "10473108253681171589-0",
        # "callSetName": "CALLSET0",
        # "genotype": [
        # 1,
        # 1
        # ],
        # `
        # ]
        # `
        # This may be the desired outcome, but it is up to the user to determine if
        # if that is indeed the case.
        # @param [Google::Apis::GenomicsV1::MergeVariantsRequest] merge_variants_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Empty] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Empty]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def merge_variants(merge_variants_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/variants:merge', options)
          command.request_representation = Google::Apis::GenomicsV1::MergeVariantsRequest::Representation
          command.request_object = merge_variants_request_object
          command.response_representation = Google::Apis::GenomicsV1::Empty::Representation
          command.response_class = Google::Apis::GenomicsV1::Empty
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Creates a new variant.
        # For the definitions of variants and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [Google::Apis::GenomicsV1::Variant] variant_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Variant] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Variant]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def create_variant(variant_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/variants', options)
          command.request_representation = Google::Apis::GenomicsV1::Variant::Representation
          command.request_object = variant_object
          command.response_representation = Google::Apis::GenomicsV1::Variant::Representation
          command.response_class = Google::Apis::GenomicsV1::Variant
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets a list of variants matching the criteria.
        # For the definitions of variants and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Implements
        # [GlobalAllianceApi.searchVariants](https://github.com/ga4gh/schemas/blob/v0.5.
        # 1/src/main/resources/avro/variantmethods.avdl#L126).
        # @param [Google::Apis::GenomicsV1::SearchVariantsRequest] search_variants_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::SearchVariantsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::SearchVariantsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def search_variants(search_variants_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/variants/search', options)
          command.request_representation = Google::Apis::GenomicsV1::SearchVariantsRequest::Representation
          command.request_object = search_variants_request_object
          command.response_representation = Google::Apis::GenomicsV1::SearchVariantsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::SearchVariantsResponse
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets a variant by ID.
        # For the definitions of variants and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] variant_id
        #   The ID of the variant.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Variant] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Variant]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def get_variant(variant_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/variants/{variantId}', options)
          command.response_representation = Google::Apis::GenomicsV1::Variant::Representation
          command.response_class = Google::Apis::GenomicsV1::Variant
          command.params['variantId'] = variant_id unless variant_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Updates a variant.
        # For the definitions of variants and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # This method supports patch semantics. Returns the modified variant without
        # its calls.
        # @param [String] variant_id
        #   The ID of the variant to be updated.
        # @param [Google::Apis::GenomicsV1::Variant] variant_object
        # @param [String] update_mask
        #   An optional mask specifying which fields to update. At this time, mutable
        #   fields are names and
        #   info. Acceptable values are "names" and
        #   "info". If unspecified, all mutable fields will be updated.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Variant] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Variant]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def patch_variant(variant_id, variant_object = nil, update_mask: nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:patch, 'v1/variants/{variantId}', options)
          command.request_representation = Google::Apis::GenomicsV1::Variant::Representation
          command.request_object = variant_object
          command.response_representation = Google::Apis::GenomicsV1::Variant::Representation
          command.response_class = Google::Apis::GenomicsV1::Variant
          command.params['variantId'] = variant_id unless variant_id.nil?
          command.query['updateMask'] = update_mask unless update_mask.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Searches for references which match the given criteria.
        # For the definitions of references and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Implements
        # [GlobalAllianceApi.searchReferences](https://github.com/ga4gh/schemas/blob/v0.
        # 5.1/src/main/resources/avro/referencemethods.avdl#L146).
        # @param [Google::Apis::GenomicsV1::SearchReferencesRequest] search_references_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::SearchReferencesResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::SearchReferencesResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def search_references(search_references_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/references/search', options)
          command.request_representation = Google::Apis::GenomicsV1::SearchReferencesRequest::Representation
          command.request_object = search_references_request_object
          command.response_representation = Google::Apis::GenomicsV1::SearchReferencesResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::SearchReferencesResponse
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets a reference.
        # For the definitions of references and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Implements
        # [GlobalAllianceApi.getReference](https://github.com/ga4gh/schemas/blob/v0.5.1/
        # src/main/resources/avro/referencemethods.avdl#L158).
        # @param [String] reference_id
        #   The ID of the reference.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Reference] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Reference]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def get_reference(reference_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/references/{referenceId}', options)
          command.response_representation = Google::Apis::GenomicsV1::Reference::Representation
          command.response_class = Google::Apis::GenomicsV1::Reference
          command.params['referenceId'] = reference_id unless reference_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Lists the bases in a reference, optionally restricted to a range.
        # For the definitions of references and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Implements
        # [GlobalAllianceApi.getReferenceBases](https://github.com/ga4gh/schemas/blob/v0.
        # 5.1/src/main/resources/avro/referencemethods.avdl#L221).
        # @param [String] reference_id
        #   The ID of the reference.
        # @param [String] end_position
        #   The end position (0-based, exclusive) of this query. Defaults to the length
        #   of this reference.
        # @param [String] page_token
        #   The continuation token, which is used to page through large result sets.
        #   To get the next page of results, set this parameter to the value of
        #   `nextPageToken` from the previous response.
        # @param [Fixnum] page_size
        #   The maximum number of bases to return in a single page. If unspecified,
        #   defaults to 200Kbp (kilo base pairs). The maximum value is 10Mbp (mega base
        #   pairs).
        # @param [String] start_position
        #   The start position (0-based) of this query. Defaults to 0.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::ListBasesResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::ListBasesResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def list_reference_bases(reference_id, end_position: nil, page_token: nil, page_size: nil, start_position: nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/references/{referenceId}/bases', options)
          command.response_representation = Google::Apis::GenomicsV1::ListBasesResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::ListBasesResponse
          command.params['referenceId'] = reference_id unless reference_id.nil?
          command.query['end'] = end_position unless end_position.nil?
          command.query['pageToken'] = page_token unless page_token.nil?
          command.query['pageSize'] = page_size unless page_size.nil?
          command.query['start'] = start_position unless start_position.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets the access control policy for the dataset. This is empty if the
        # policy or resource does not exist.
        # See <a href="/iam/docs/managing-policies#getting_a_policy">Getting a
        # Policy</a> for more information.
        # For the definitions of datasets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] resource
        #   REQUIRED: The resource for which policy is being specified. Format is
        #   `datasets/<dataset ID>`.
        # @param [Google::Apis::GenomicsV1::GetIamPolicyRequest] get_iam_policy_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Policy] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Policy]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def get_dataset_iam_policy(resource, get_iam_policy_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/{+resource}:getIamPolicy', options)
          command.request_representation = Google::Apis::GenomicsV1::GetIamPolicyRequest::Representation
          command.request_object = get_iam_policy_request_object
          command.response_representation = Google::Apis::GenomicsV1::Policy::Representation
          command.response_class = Google::Apis::GenomicsV1::Policy
          command.params['resource'] = resource unless resource.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Undeletes a dataset by restoring a dataset which was deleted via this API.
        # For the definitions of datasets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # This operation is only possible for a week after the deletion occurred.
        # @param [String] dataset_id
        #   The ID of the dataset to be undeleted.
        # @param [Google::Apis::GenomicsV1::UndeleteDatasetRequest] undelete_dataset_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Dataset] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Dataset]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def undelete_dataset(dataset_id, undelete_dataset_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/datasets/{datasetId}:undelete', options)
          command.request_representation = Google::Apis::GenomicsV1::UndeleteDatasetRequest::Representation
          command.request_object = undelete_dataset_request_object
          command.response_representation = Google::Apis::GenomicsV1::Dataset::Representation
          command.response_class = Google::Apis::GenomicsV1::Dataset
          command.params['datasetId'] = dataset_id unless dataset_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets a dataset by ID.
        # For the definitions of datasets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] dataset_id
        #   The ID of the dataset.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Dataset] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Dataset]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def get_dataset(dataset_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/datasets/{datasetId}', options)
          command.response_representation = Google::Apis::GenomicsV1::Dataset::Representation
          command.response_class = Google::Apis::GenomicsV1::Dataset
          command.params['datasetId'] = dataset_id unless dataset_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Updates a dataset.
        # For the definitions of datasets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # This method supports patch semantics.
        # @param [String] dataset_id
        #   The ID of the dataset to be updated.
        # @param [Google::Apis::GenomicsV1::Dataset] dataset_object
        # @param [String] update_mask
        #   An optional mask specifying which fields to update. At this time, the only
        #   mutable field is name. The only
        #   acceptable value is "name". If unspecified, all mutable fields will be
        #   updated.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Dataset] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Dataset]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def patch_dataset(dataset_id, dataset_object = nil, update_mask: nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:patch, 'v1/datasets/{datasetId}', options)
          command.request_representation = Google::Apis::GenomicsV1::Dataset::Representation
          command.request_object = dataset_object
          command.response_representation = Google::Apis::GenomicsV1::Dataset::Representation
          command.response_class = Google::Apis::GenomicsV1::Dataset
          command.params['datasetId'] = dataset_id unless dataset_id.nil?
          command.query['updateMask'] = update_mask unless update_mask.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Returns permissions that a caller has on the specified resource.
        # See <a href="/iam/docs/managing-policies#testing_permissions">Testing
        # Permissions</a> for more information.
        # For the definitions of datasets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] resource
        #   REQUIRED: The resource for which policy is being specified. Format is
        #   `datasets/<dataset ID>`.
        # @param [Google::Apis::GenomicsV1::TestIamPermissionsRequest] test_iam_permissions_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::TestIamPermissionsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::TestIamPermissionsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def test_dataset_iam_permissions(resource, test_iam_permissions_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/{+resource}:testIamPermissions', options)
          command.request_representation = Google::Apis::GenomicsV1::TestIamPermissionsRequest::Representation
          command.request_object = test_iam_permissions_request_object
          command.response_representation = Google::Apis::GenomicsV1::TestIamPermissionsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::TestIamPermissionsResponse
          command.params['resource'] = resource unless resource.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Deletes a dataset and all of its contents (all read group sets,
        # reference sets, variant sets, call sets, annotation sets, etc.)
        # This is reversible (up to one week after the deletion) via
        # the
        # datasets.undelete
        # operation.
        # For the definitions of datasets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] dataset_id
        #   The ID of the dataset to be deleted.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Empty] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Empty]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def delete_dataset(dataset_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:delete, 'v1/datasets/{datasetId}', options)
          command.response_representation = Google::Apis::GenomicsV1::Empty::Representation
          command.response_class = Google::Apis::GenomicsV1::Empty
          command.params['datasetId'] = dataset_id unless dataset_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Lists datasets within a project.
        # For the definitions of datasets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [Fixnum] page_size
        #   The maximum number of results to return in a single page. If unspecified,
        #   defaults to 50. The maximum value is 1024.
        # @param [String] project_id
        #   Required. The Google Cloud project ID to list datasets for.
        # @param [String] page_token
        #   The continuation token, which is used to page through large result sets.
        #   To get the next page of results, set this parameter to the value of
        #   `nextPageToken` from the previous response.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::ListDatasetsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::ListDatasetsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def list_datasets(page_size: nil, project_id: nil, page_token: nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/datasets', options)
          command.response_representation = Google::Apis::GenomicsV1::ListDatasetsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::ListDatasetsResponse
          command.query['pageSize'] = page_size unless page_size.nil?
          command.query['projectId'] = project_id unless project_id.nil?
          command.query['pageToken'] = page_token unless page_token.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Creates a new dataset.
        # For the definitions of datasets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [Google::Apis::GenomicsV1::Dataset] dataset_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Dataset] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Dataset]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def create_dataset(dataset_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/datasets', options)
          command.request_representation = Google::Apis::GenomicsV1::Dataset::Representation
          command.request_object = dataset_object
          command.response_representation = Google::Apis::GenomicsV1::Dataset::Representation
          command.response_class = Google::Apis::GenomicsV1::Dataset
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Sets the access control policy on the specified dataset. Replaces any
        # existing policy.
        # For the definitions of datasets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # See <a href="/iam/docs/managing-policies#setting_a_policy">Setting a
        # Policy</a> for more information.
        # @param [String] resource
        #   REQUIRED: The resource for which policy is being specified. Format is
        #   `datasets/<dataset ID>`.
        # @param [Google::Apis::GenomicsV1::SetIamPolicyRequest] set_iam_policy_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Policy] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Policy]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def set_dataset_iam_policy(resource, set_iam_policy_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/{+resource}:setIamPolicy', options)
          command.request_representation = Google::Apis::GenomicsV1::SetIamPolicyRequest::Representation
          command.request_object = set_iam_policy_request_object
          command.response_representation = Google::Apis::GenomicsV1::Policy::Representation
          command.response_class = Google::Apis::GenomicsV1::Policy
          command.params['resource'] = resource unless resource.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Deletes a variant set including all variants, call sets, and calls within.
        # This is not reversible.
        # For the definitions of variant sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] variant_set_id
        #   The ID of the variant set to be deleted.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Empty] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Empty]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def delete_variantset(variant_set_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:delete, 'v1/variantsets/{variantSetId}', options)
          command.response_representation = Google::Apis::GenomicsV1::Empty::Representation
          command.response_class = Google::Apis::GenomicsV1::Empty
          command.params['variantSetId'] = variant_set_id unless variant_set_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Creates a new variant set.
        # For the definitions of variant sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # The provided variant set must have a valid `datasetId` set - all other
        # fields are optional. Note that the `id` field will be ignored, as this is
        # assigned by the server.
        # @param [Google::Apis::GenomicsV1::VariantSet] variant_set_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::VariantSet] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::VariantSet]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def create_variantset(variant_set_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/variantsets', options)
          command.request_representation = Google::Apis::GenomicsV1::VariantSet::Representation
          command.request_object = variant_set_object
          command.response_representation = Google::Apis::GenomicsV1::VariantSet::Representation
          command.response_class = Google::Apis::GenomicsV1::VariantSet
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Exports variant set data to an external destination.
        # For the definitions of variant sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] variant_set_id
        #   Required. The ID of the variant set that contains variant data which
        #   should be exported. The caller must have READ access to this variant set.
        # @param [Google::Apis::GenomicsV1::ExportVariantSetRequest] export_variant_set_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Operation] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Operation]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def export_variant_set(variant_set_id, export_variant_set_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/variantsets/{variantSetId}:export', options)
          command.request_representation = Google::Apis::GenomicsV1::ExportVariantSetRequest::Representation
          command.request_object = export_variant_set_request_object
          command.response_representation = Google::Apis::GenomicsV1::Operation::Representation
          command.response_class = Google::Apis::GenomicsV1::Operation
          command.params['variantSetId'] = variant_set_id unless variant_set_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Returns a list of all variant sets matching search criteria.
        # For the definitions of variant sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Implements
        # [GlobalAllianceApi.searchVariantSets](https://github.com/ga4gh/schemas/blob/v0.
        # 5.1/src/main/resources/avro/variantmethods.avdl#L49).
        # @param [Google::Apis::GenomicsV1::SearchVariantSetsRequest] search_variant_sets_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::SearchVariantSetsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::SearchVariantSetsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def search_variant_sets(search_variant_sets_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/variantsets/search', options)
          command.request_representation = Google::Apis::GenomicsV1::SearchVariantSetsRequest::Representation
          command.request_object = search_variant_sets_request_object
          command.response_representation = Google::Apis::GenomicsV1::SearchVariantSetsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::SearchVariantSetsResponse
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Updates a variant set using patch semantics.
        # For the definitions of variant sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] variant_set_id
        #   The ID of the variant to be updated (must already exist).
        # @param [Google::Apis::GenomicsV1::VariantSet] variant_set_object
        # @param [String] update_mask
        #   An optional mask specifying which fields to update. Supported fields:
        #   * metadata.
        #   * name.
        #   * description.
        #   Leaving `updateMask` unset is equivalent to specifying all mutable
        #   fields.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::VariantSet] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::VariantSet]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def patch_variantset(variant_set_id, variant_set_object = nil, update_mask: nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:patch, 'v1/variantsets/{variantSetId}', options)
          command.request_representation = Google::Apis::GenomicsV1::VariantSet::Representation
          command.request_object = variant_set_object
          command.response_representation = Google::Apis::GenomicsV1::VariantSet::Representation
          command.response_class = Google::Apis::GenomicsV1::VariantSet
          command.params['variantSetId'] = variant_set_id unless variant_set_id.nil?
          command.query['updateMask'] = update_mask unless update_mask.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets a variant set by ID.
        # For the definitions of variant sets and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # @param [String] variant_set_id
        #   Required. The ID of the variant set.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::VariantSet] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::VariantSet]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def get_variantset(variant_set_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/variantsets/{variantSetId}', options)
          command.response_representation = Google::Apis::GenomicsV1::VariantSet::Representation
          command.response_class = Google::Apis::GenomicsV1::VariantSet
          command.params['variantSetId'] = variant_set_id unless variant_set_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Creates a new annotation. Caller must have WRITE permission
        # for the associated annotation set.
        # The following fields are required:
        # * annotationSetId
        # * referenceName or
        # referenceId
        # ### Transcripts
        # For annotations of type TRANSCRIPT, the following fields of
        # transcript must be provided:
        # * exons.start
        # * exons.end
        # All other fields may be optionally specified, unless documented as being
        # server-generated (for example, the `id` field). The annotated
        # range must be no longer than 100Mbp (mega base pairs). See the
        # Annotation resource
        # for additional restrictions on each field.
        # @param [Google::Apis::GenomicsV1::Annotation] annotation_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Annotation] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Annotation]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def create_annotation(annotation_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/annotations', options)
          command.request_representation = Google::Apis::GenomicsV1::Annotation::Representation
          command.request_object = annotation_object
          command.response_representation = Google::Apis::GenomicsV1::Annotation::Representation
          command.response_class = Google::Apis::GenomicsV1::Annotation
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Creates one or more new annotations atomically. All annotations must
        # belong to the same annotation set. Caller must have WRITE
        # permission for this annotation set. For optimal performance, batch
        # positionally adjacent annotations together.
        # If the request has a systemic issue, such as an attempt to write to
        # an inaccessible annotation set, the entire RPC will fail accordingly. For
        # lesser data issues, when possible an error will be isolated to the
        # corresponding batch entry in the response; the remaining well formed
        # annotations will be created normally.
        # For details on the requirements for each individual annotation resource,
        # see
        # CreateAnnotation.
        # @param [Google::Apis::GenomicsV1::BatchCreateAnnotationsRequest] batch_create_annotations_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::BatchCreateAnnotationsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::BatchCreateAnnotationsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def batch_create_annotations(batch_create_annotations_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/annotations:batchCreate', options)
          command.request_representation = Google::Apis::GenomicsV1::BatchCreateAnnotationsRequest::Representation
          command.request_object = batch_create_annotations_request_object
          command.response_representation = Google::Apis::GenomicsV1::BatchCreateAnnotationsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::BatchCreateAnnotationsResponse
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Searches for annotations that match the given criteria. Results are
        # ordered by genomic coordinate (by reference sequence, then position).
        # Annotations with equivalent genomic coordinates are returned in an
        # unspecified order. This order is consistent, such that two queries for the
        # same content (regardless of page size) yield annotations in the same order
        # across their respective streams of paginated responses. Caller must have
        # READ permission for the queried annotation sets.
        # @param [Google::Apis::GenomicsV1::SearchAnnotationsRequest] search_annotations_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::SearchAnnotationsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::SearchAnnotationsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def search_annotations(search_annotations_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/annotations/search', options)
          command.request_representation = Google::Apis::GenomicsV1::SearchAnnotationsRequest::Representation
          command.request_object = search_annotations_request_object
          command.response_representation = Google::Apis::GenomicsV1::SearchAnnotationsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::SearchAnnotationsResponse
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets an annotation. Caller must have READ permission
        # for the associated annotation set.
        # @param [String] annotation_id
        #   The ID of the annotation to be retrieved.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Annotation] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Annotation]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def get_annotation(annotation_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/annotations/{annotationId}', options)
          command.response_representation = Google::Apis::GenomicsV1::Annotation::Representation
          command.response_class = Google::Apis::GenomicsV1::Annotation
          command.params['annotationId'] = annotation_id unless annotation_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Updates an annotation. Caller must have
        # WRITE permission for the associated dataset.
        # @param [String] annotation_id
        #   The ID of the annotation to be updated.
        # @param [Google::Apis::GenomicsV1::Annotation] annotation_object
        # @param [String] update_mask
        #   An optional mask specifying which fields to update. Mutable fields are
        #   name,
        #   variant,
        #   transcript, and
        #   info. If unspecified, all mutable
        #   fields will be updated.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Annotation] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Annotation]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def update_annotation(annotation_id, annotation_object = nil, update_mask: nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:put, 'v1/annotations/{annotationId}', options)
          command.request_representation = Google::Apis::GenomicsV1::Annotation::Representation
          command.request_object = annotation_object
          command.response_representation = Google::Apis::GenomicsV1::Annotation::Representation
          command.response_class = Google::Apis::GenomicsV1::Annotation
          command.params['annotationId'] = annotation_id unless annotation_id.nil?
          command.query['updateMask'] = update_mask unless update_mask.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Deletes an annotation. Caller must have WRITE permission for
        # the associated annotation set.
        # @param [String] annotation_id
        #   The ID of the annotation to be deleted.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Empty] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Empty]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def delete_annotation(annotation_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:delete, 'v1/annotations/{annotationId}', options)
          command.response_representation = Google::Apis::GenomicsV1::Empty::Representation
          command.response_class = Google::Apis::GenomicsV1::Empty
          command.params['annotationId'] = annotation_id unless annotation_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Starts asynchronous cancellation on a long-running operation. The server makes
        # a best effort to cancel the operation, but success is not guaranteed. Clients
        # may use Operations.GetOperation or Operations.ListOperations to check whether
        # the cancellation succeeded or the operation completed despite cancellation.
        # @param [String] name
        #   The name of the operation resource to be cancelled.
        # @param [Google::Apis::GenomicsV1::CancelOperationRequest] cancel_operation_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Empty] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Empty]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def cancel_operation(name, cancel_operation_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/{+name}:cancel', options)
          command.request_representation = Google::Apis::GenomicsV1::CancelOperationRequest::Representation
          command.request_object = cancel_operation_request_object
          command.response_representation = Google::Apis::GenomicsV1::Empty::Representation
          command.response_class = Google::Apis::GenomicsV1::Empty
          command.params['name'] = name unless name.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Lists operations that match the specified filter in the request.
        # @param [String] name
        #   The name of the operation collection.
        # @param [Fixnum] page_size
        #   The maximum number of results to return. If unspecified, defaults to
        #   256. The maximum value is 2048.
        # @param [String] filter
        #   A string for filtering Operations.
        #   The following filter fields are supported&#58;
        #   * projectId&#58; Required. Corresponds to
        #   OperationMetadata.projectId.
        #   * createTime&#58; The time this job was created, in seconds from the
        #   [epoch](http://en.wikipedia.org/wiki/Unix_time). Can use `>=` and/or `<=`
        #   operators.
        #   * status&#58; Can be `RUNNING`, `SUCCESS`, `FAILURE`, or `CANCELED`. Only
        #   one status may be specified.
        #   * labels.key where key is a label key.
        #   Examples&#58;
        #   * `projectId = my-project AND createTime >= 1432140000`
        #   * `projectId = my-project AND createTime >= 1432140000 AND createTime <=
        #   1432150000 AND status = RUNNING`
        #   * `projectId = my-project AND labels.color = *`
        #   * `projectId = my-project AND labels.color = red`
        # @param [String] page_token
        #   The standard list page token.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::ListOperationsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::ListOperationsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def list_operations(name, page_size: nil, filter: nil, page_token: nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/{+name}', options)
          command.response_representation = Google::Apis::GenomicsV1::ListOperationsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::ListOperationsResponse
          command.params['name'] = name unless name.nil?
          command.query['pageSize'] = page_size unless page_size.nil?
          command.query['filter'] = filter unless filter.nil?
          command.query['pageToken'] = page_token unless page_token.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets the latest state of a long-running operation.  Clients can use this
        # method to poll the operation result at intervals as recommended by the API
        # service.
        # @param [String] name
        #   The name of the operation resource.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::Operation] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::Operation]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def get_operation(name, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/{+name}', options)
          command.response_representation = Google::Apis::GenomicsV1::Operation::Representation
          command.response_class = Google::Apis::GenomicsV1::Operation
          command.params['name'] = name unless name.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Searches for reference sets which match the given criteria.
        # For the definitions of references and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Implements
        # [GlobalAllianceApi.searchReferenceSets](https://github.com/ga4gh/schemas/blob/
        # v0.5.1/src/main/resources/avro/referencemethods.avdl#L71)
        # @param [Google::Apis::GenomicsV1::SearchReferenceSetsRequest] search_reference_sets_request_object
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::SearchReferenceSetsResponse] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::SearchReferenceSetsResponse]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def search_reference_sets(search_reference_sets_request_object = nil, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:post, 'v1/referencesets/search', options)
          command.request_representation = Google::Apis::GenomicsV1::SearchReferenceSetsRequest::Representation
          command.request_object = search_reference_sets_request_object
          command.response_representation = Google::Apis::GenomicsV1::SearchReferenceSetsResponse::Representation
          command.response_class = Google::Apis::GenomicsV1::SearchReferenceSetsResponse
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end
        
        # Gets a reference set.
        # For the definitions of references and other genomics resources, see
        # [Fundamentals of Google
        # Genomics](https://cloud.google.com/genomics/fundamentals-of-google-genomics)
        # Implements
        # [GlobalAllianceApi.getReferenceSet](https://github.com/ga4gh/schemas/blob/v0.5.
        # 1/src/main/resources/avro/referencemethods.avdl#L83).
        # @param [String] reference_set_id
        #   The ID of the reference set.
        # @param [String] quota_user
        #   Available to use for quota purposes for server-side applications. Can be any
        #   arbitrary string assigned to a user, but should not exceed 40 characters.
        # @param [String] fields
        #   Selector specifying which fields to include in a partial response.
        # @param [Google::Apis::RequestOptions] options
        #   Request-specific options
        #
        # @yield [result, err] Result & error if block supplied
        # @yieldparam result [Google::Apis::GenomicsV1::ReferenceSet] parsed result object
        # @yieldparam err [StandardError] error object if request failed
        #
        # @return [Google::Apis::GenomicsV1::ReferenceSet]
        #
        # @raise [Google::Apis::ServerError] An error occurred on the server and the request can be retried
        # @raise [Google::Apis::ClientError] The request is invalid and should not be retried without modification
        # @raise [Google::Apis::AuthorizationError] Authorization is required
        def get_reference_set(reference_set_id, quota_user: nil, fields: nil, options: nil, &block)
          command =  make_simple_command(:get, 'v1/referencesets/{referenceSetId}', options)
          command.response_representation = Google::Apis::GenomicsV1::ReferenceSet::Representation
          command.response_class = Google::Apis::GenomicsV1::ReferenceSet
          command.params['referenceSetId'] = reference_set_id unless reference_set_id.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
          command.query['fields'] = fields unless fields.nil?
          execute_or_queue_command(command, &block)
        end

        protected

        def apply_command_defaults(command)
          command.query['key'] = key unless key.nil?
          command.query['quotaUser'] = quota_user unless quota_user.nil?
        end
      end
    end
  end
end